Status ep. Intravenous lorazepam is better than intravenous diazepam or
intravenous phenytoin alone for cessation of seizures. Intravenous
lorazepam also carries a lower risk of continuation of status
epilepticus requiring a different drug or general anaesthesia compared
with intravenous diazepam. Both intravenous lorazepam and diazepam are
better than placebo for the same outcomes. For pre hospital management,
midazolam IM seemed more effective than lorazepam IV for cessation of
seizures, frequency of hospitalisation and ICU admissions however,it
was unclear whether the risk of recurrence of seizures differed between
treatments.
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