COVID-19 in Kids: New Neurologic, Radiographic Findings
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Children with COVID-19-related pediatric multisystem inflammatory syndrome (MIS) may experience neurologic symptoms that involve the central nervous system and the peripheral nervous system, new research suggests.
In a case-series study of 27 children with COVID-19 MIS at a hospital in London, United Kingdom, four presented with new-onset symptoms that included headache, brainstem and cerebellar signs, encephalopathy, muscle weakness, and reduced reflexes.
After the patients were admitted to an intensive care unit, MRI scans showed splenium signal changes in all four patients.
In addition, a "mild excess of slow activity" was found in the three children who underwent electroencephalography, and mild myopathic and neuropathic changes were found in the three who underwent nerve conduction measures and electromyography.
By end of study, all four showed neurologic improvement, and two had made a full recovery.
"Additional research is needed to assess the association of neurological symptoms with immune-mediated changes among children with COVID-19," write the investigators, led by Omar Abdel-Mannan, MD, Department of Neurology, Great Ormond Street Hospital for Children, London.
The findings were published online July 1 in JAMA Neurology.
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