Erythema multiforme (EM) is an immune-mediated type IV hypersensitivity reaction. EM
can be diagnosed by its characteristic targetoid lesions (erythema with central
blanching) and categorized into EM minor and EM major. EM minor consists of
cutaneous lesions primarily on the extremities, while EM major involves the mucus
membranes as well.
can be diagnosed by its characteristic targetoid lesions (erythema with central
blanching) and categorized into EM minor and EM major. EM minor consists of
cutaneous lesions primarily on the extremities, while EM major involves the mucus
membranes as well.
Herpes simplex virus-1 (HSV-1)
Explanation:
Infections are the most common cause of erythema multiforme with HSV being the most
commonly identified precipitant in greater than 70% of cases. Several categories of
medications have been reported to cause this rash and include sulfonamides,
non-steroidal anti-inflammatory drugs, and penicillins.
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