LONG TTN., OVER 72 HRS

Lactate and LDH might be useful for clinicians at first level hospitals for decision making to refer the TTN patient to the secondary or tertiary level neonatal intensive care unit before the clinical situation is worsened.

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Term infants with TTN had low lamellar body counts associated with decreased surfactant function, suggesting that prolonged disease is associated with surfactant abnormalities.

Male gender, prematurity and delivery by cesarean section were the major risk factors for TTN. Parenteral furosemide had no effect on the clinical course. Peak respiratory rate (RRpeak) at the first 36 h was significantly higher in group 2 (P > 0.000). The cut-off for RRpeak during the first 36 h (RRpeak36) was 90/min and RRpeak36 > 90/min caused a 7.04-fold risk of prolongedtachypnea. White blood cell count and hematocrit levels were lower whereas duration of hospitalization and antibiotic treatment were longer in group 2.

CONCLUSIONS:

Assessment of RRpeak36 may be useful in predicting clinical course of TTN.

Initially prolonged RVSTI RT VENTR SYTOLIC TIME INTERVAL was best predictor of the development of severe TTN (relative risk ratio 17.5, p less than 0.001): clinical characteristics and oxygen requirements at the admission had limited predictive value.