///////////////////////GREAT FOODS=VERY HEALTHFUL VEGGIES
The fresher the food, the more nutritious it generally is, so we shop several times each week. We go to a nearby health-food store for locally grown produce (which hasn't spent days in transit) and organic products (which aren't contaminated with pesticides) and head straight for the vegetables.
Eggplant, which Angela adores, is often the first item in our cart. The skin is a rich source of nasunin, a potent antioxidant (a substance that neutralizes disease-causing molecules called free radicals). Eggplant provides minerals that promote good circulation and/or strong bones, including potassium, manganese, copper and magnesium... plus B vitamins for heart health, including B-1 (thiamine), B-3 (niacin), B-6 (pyridoxine) and B-9 (folate). This versatile vegetable can be diced and stir-fried... thin-sliced and grilled... or cut in half, oven-baked until tender (about 20 minutes at 350 degrees), then topped with cottage cheese. Note: Avoid eggplant if its alkaloids (organic compounds) aggravate your arthritis.
Beets help to detoxify the body by raising levels of the antioxidant glutathione in the liver... improve gallbladder function by thinning bile (a digestive fluid)... and provide folate and manganese for joint health. Red beets provide the most betacyanin, a plant pigment that protects against colon cancer. Beets can be combined with carrots and juiced... grated and added to salads... or cut into chunks and roasted.
Broccoli contains the antioxidants sulforaphane and chlorophyl... vitamins A, C and E, which strengthen the immune system... calcium and vitamin K for bone health... folate for normal cell division... and lutein (a plant pigment) for eye health. Cauliflower provides many of the same phytonutrients (beneficial plant chemicals) as broccoli.
Carrots pack easily into lunch boxes. We love baby carrots dipped in salad dressing, so we buy dressings with no unhealthful hydrogenated fat, high-fructose corn syrup or monosodium glutamate (MSG), a salty additive. For carrot juice, we peel large carrots and put them in our Vita-Mix (from $399, 800-848-2649, http://link.bls.bottomlinesecrets.com/h/Q648/KLV5/QR/EU522), a high-power blender that preserves the fiber-rich pulp of fruits and vegetables.
Cabbage is a super source of vitamin K (for bone health)... vitamin C (for tissue growth and repair)... and organic compounds called indoles (for cancer prevention). Red cabbage has more healthful plant pigments than white. Since its juice has a very mild flavor, Angela adds red cabbage to almost everything we make in the Vita-Mix. Our kids get a kick from the looks on their friends' faces when we add cabbage to a fruit sorbet or fruit smoothie -- and it's even more fun when their friends love the taste!
Cherry tomatoes, rich in vitamins A and C, taste great with sliced low-fat mozzarella cheese.
Salad greens we eat daily include romaine, red- or green-leaf lettuce and fresh spinach. They provide vitamin K, as well as fiber for bowel regularity.
FAVORITE FRUITS
We love fresh fruit for snacks and desserts.
Mango, one of my favorites, is rich in fiber, beta-carotene, magnesium, potassium and vitamins B-1, B-2 (riboflavin), B-3 and B-6. Sweet, tangy and juicy, mangoes make a delicious (if messy) snack when peeled and sliced. Mango slices also can be added to green salad and fruit smoothies or baked in pies.
Kiwifruit -- fuzzy brown outside, brilliant green inside -- is packed with vitamin C. The kiwifruit is a natural blood thinner that reduces blood levels of triglycerides (fats). Peel and slice to eat alone, add to a fruit salad, or blend into a smoothie.
Apricots are rich in vitamin A and healthful plant pigments called carotenoids (such as beta-carotene and lycopene), which aid vision. Lycopene also may fight heart disease and prostate problems.
Apples provide fiber plus heart-healthy quercetin. Slice and spread with almond butter (for protein), or sprinkle with cinnamon (to balance blood sugar).
Bananas are rich in potassium, to maintain normal blood pressure and heart function... and provide B vitamins, which help to balance brain chemicals called neurotransmitters. Our after-dinner snack often consists of bananas with cinnamon or peanut butter.
Blueberries contain purplish pigments called anthocyanins (also found in red grapes and cranberries), which fight urinary tract infections and may protect the brain from oxidative stress, reducing the effects of dementia. Blueberries have vitamin E and other nutrients that strengthen blood vessels.
Oranges have more than 170 phytonutrients and more than 60 flavonoids (healthful plant pigments) that fight inflammation, blood clots and various cancers. Other citrus fruits provide similar benefits.
Avocados are rich in oleic acid, a monounsaturated fat that lowers LDL "bad" cholesterol. Peel and slice them into salads, add them to burritos, or mash as a sandwich spread.
BODY-BUILDING PROTEINS
Protein is required for muscle and tissue repair, blood sugar balance and proper immune function.
Eggs we buy are organic (laid by chickens that eat grains free of chemicals and that are not treated with hormones or antibiotics) and enriched with omega-3 fatty acids for cardiovascular health. We each have three to five eggs weekly -- boiled, poached or scrambled with cheese.
Poultry (skin removed) is typically lower in saturated fat than red meat and therefore is healthier for the cardiovascular system. We select poultry labeled "free range" (meaning the animals were not constantly caged and were not fed antibiotics). From the deli counter, we buy cooked, sliced turkey and chicken breast for sandwiches, opting for low-sodium, preservative-free brands. Favorite dinner entrées include turkey loaf (ground turkey can be substituted for beef and pork in meat loaf recipes) and pan-fried or broiled turkey burgers. We also love Angela's baked chicken breasts, seasoned with rosemary, lemon and poultry seasoning. We seldom barbecue meat or poultry because doing so creates cancer-causing compounds called heterocyclic amines (HCAs).
Wild ocean salmon (which we consider to be more healthful than farm-raised) we buy when it is in season, to bake or broil with olive oil and lemon. In addition to being low in calories and saturated fat, salmon is high in protein... omega-3s... vitamins B-3, B-6 and B-12 (cobalamin)... phosphorous... and magnesium. We avoid tuna -- including canned -- due to concerns about mercury contamination. However, canned ocean salmon packed in water is healthful, as are canned sardines -- though I confess that we do not enjoy the taste (or smell) of sardines.
Cheeses we enjoy in moderation include Colby and string cheese for snacks and shredded cheddar on burritos. Along with protein and calcium, cheese provides the amino acid tryptophan, which promotes thyroid function and positive moods.
cans, cartons & Jars
Packaged goods can be healthful, provided they don't have added preservatives, oils, sugars or salt.
Beans are a must for Mexican-style tostados. Their soluble fiber promotes proper cholesterol and blood sugar levels. Black beans are rich in antioxidant anthocyanins. Pinto beans have magnesium, potassium, manganese, copper and molybdenum, which help the liver with detoxification.
Almond milk is rich in potassium. Blue Diamond's unsweetened almond milk tastes great in cereal and scrambled eggs. A sweetened brand called Almond Breeze has 7 grams (g) of sugar per eight-ounce serving. We pour it over hot oatmeal and drink it as a snack. We also buy oat milk and rice milk. (We avoid drinking cow's milk because it can cause allergic and immune reactions and digestive distress.)
Peanut butter is a passion for our kids (and our dog, Blast). We buy pure peanut butter (in a glass container to avoid chemicals that may leach from plastics) that has no added sugar or partially hydrogenated fat. Peanut butter has heart-healthy monounsaturated fats, vitamin E, niacin, folate, manganese and resveratrol (the same antioxidant found in red wine). We also like almond butter, which is similar in nutrient content.
GREAT GRAINS & OTHER GOODIES
Selecting grains can be complicated for people who -- like my youngest son and me -- experience nasal congestion, bloating and diarrhea after consuming foods with gluten (a protein complex). Wheat, rye and barley all contain gluten.
Gluten-free grains include corn, amaranth, rice, buckwheat and quinoa. Of the gluten-free breads we have tried, those from Kinnikinnick Foods (877-503-4466, http://link.bls.bottomlinesecrets.com/h/KL2H/KLV5/QR/EU522) taste best. Pastas, cereals, pretzels, corn chips, tortillas and tostado shells also come in gluten-free varieties.
Cereals we select have no more than 3 g of sugar and provide at least 2 g to 3 g of fiber per serving. Favorites include Rice Crunch-Ems from Health Valley... Amazon Frosted Flakes from Nature's Path... and Kix or Cheerios from General Mills. We also get oatmeal -- a source of energy-sustaining complex carbohydrates, as well as manganese, selenium and silicon, which promote bone and cartilage health. The slow-cooking kind has the most fiber.
Seeds and nuts are on our list, too. I grind up two tablespoons of flaxseeds each morning, place them on my tongue, and wash them down with water. Flaxseeds provide fiber and essential fatty acids, and may combat cancer. Hemp seeds are high in protein and omega-3s. Almonds and walnuts are rich in antioxidants and omega-3s, respectively. Angela and I eat one-quarter cup daily, and we try to get our kids to eat a few.
Chips are big hits, especially bruschetta chips from Wild Oats (800-494-9453, http://link.bls.bottomlinesecrets.com/h/V2YA/KLV5/QR/EU522). Made with potatoes, tomatoes, basil and olive oil, they provide protein and fiber but no sugar or saturated fat.
Oils are important to good cooks (like Angela). Extra-virgin olive oil is what we use when cooking fish and chicken or roasting vegetables. Its monounsaturated fats promote cardiovascular health. To scramble eggs, we use organic canola oil, which contains vitamin E and omega-3s. Macadamia nut oil is best for stir-frying because it has a higher smoke point (the temperature at which a cooking oil breaks down and smokes, giving food an unpleasant taste).
Fun foods we enjoy without guilt include Rice Dream Bars (ice cream bars made from rice milk)... Newman's Own brand fig cookies... Ghirardelli semisweet chocolate chips... and SunSpire carob chips.
Eating healthfully comes at a premium. The price of organic foods is about 25% higher than the cost of foods that may have been grown using pesticides or made with unhealthful processing methods. We are happy to pay the price because our family's health is worth it. I suspect you feel the same way.
The fresher the food, the more nutritious it generally is, so we shop several times each week. We go to a nearby health-food store for locally grown produce (which hasn't spent days in transit) and organic products (which aren't contaminated with pesticides) and head straight for the vegetables.
Eggplant, which Angela adores, is often the first item in our cart. The skin is a rich source of nasunin, a potent antioxidant (a substance that neutralizes disease-causing molecules called free radicals). Eggplant provides minerals that promote good circulation and/or strong bones, including potassium, manganese, copper and magnesium... plus B vitamins for heart health, including B-1 (thiamine), B-3 (niacin), B-6 (pyridoxine) and B-9 (folate). This versatile vegetable can be diced and stir-fried... thin-sliced and grilled... or cut in half, oven-baked until tender (about 20 minutes at 350 degrees), then topped with cottage cheese. Note: Avoid eggplant if its alkaloids (organic compounds) aggravate your arthritis.
Beets help to detoxify the body by raising levels of the antioxidant glutathione in the liver... improve gallbladder function by thinning bile (a digestive fluid)... and provide folate and manganese for joint health. Red beets provide the most betacyanin, a plant pigment that protects against colon cancer. Beets can be combined with carrots and juiced... grated and added to salads... or cut into chunks and roasted.
Broccoli contains the antioxidants sulforaphane and chlorophyl... vitamins A, C and E, which strengthen the immune system... calcium and vitamin K for bone health... folate for normal cell division... and lutein (a plant pigment) for eye health. Cauliflower provides many of the same phytonutrients (beneficial plant chemicals) as broccoli.
Carrots pack easily into lunch boxes. We love baby carrots dipped in salad dressing, so we buy dressings with no unhealthful hydrogenated fat, high-fructose corn syrup or monosodium glutamate (MSG), a salty additive. For carrot juice, we peel large carrots and put them in our Vita-Mix (from $399, 800-848-2649, http://link.bls.bottomlinesecrets.com/h/Q648/KLV5/QR/EU522), a high-power blender that preserves the fiber-rich pulp of fruits and vegetables.
Cabbage is a super source of vitamin K (for bone health)... vitamin C (for tissue growth and repair)... and organic compounds called indoles (for cancer prevention). Red cabbage has more healthful plant pigments than white. Since its juice has a very mild flavor, Angela adds red cabbage to almost everything we make in the Vita-Mix. Our kids get a kick from the looks on their friends' faces when we add cabbage to a fruit sorbet or fruit smoothie -- and it's even more fun when their friends love the taste!
Cherry tomatoes, rich in vitamins A and C, taste great with sliced low-fat mozzarella cheese.
Salad greens we eat daily include romaine, red- or green-leaf lettuce and fresh spinach. They provide vitamin K, as well as fiber for bowel regularity.
FAVORITE FRUITS
We love fresh fruit for snacks and desserts.
Mango, one of my favorites, is rich in fiber, beta-carotene, magnesium, potassium and vitamins B-1, B-2 (riboflavin), B-3 and B-6. Sweet, tangy and juicy, mangoes make a delicious (if messy) snack when peeled and sliced. Mango slices also can be added to green salad and fruit smoothies or baked in pies.
Kiwifruit -- fuzzy brown outside, brilliant green inside -- is packed with vitamin C. The kiwifruit is a natural blood thinner that reduces blood levels of triglycerides (fats). Peel and slice to eat alone, add to a fruit salad, or blend into a smoothie.
Apricots are rich in vitamin A and healthful plant pigments called carotenoids (such as beta-carotene and lycopene), which aid vision. Lycopene also may fight heart disease and prostate problems.
Apples provide fiber plus heart-healthy quercetin. Slice and spread with almond butter (for protein), or sprinkle with cinnamon (to balance blood sugar).
Bananas are rich in potassium, to maintain normal blood pressure and heart function... and provide B vitamins, which help to balance brain chemicals called neurotransmitters. Our after-dinner snack often consists of bananas with cinnamon or peanut butter.
Blueberries contain purplish pigments called anthocyanins (also found in red grapes and cranberries), which fight urinary tract infections and may protect the brain from oxidative stress, reducing the effects of dementia. Blueberries have vitamin E and other nutrients that strengthen blood vessels.
Oranges have more than 170 phytonutrients and more than 60 flavonoids (healthful plant pigments) that fight inflammation, blood clots and various cancers. Other citrus fruits provide similar benefits.
Avocados are rich in oleic acid, a monounsaturated fat that lowers LDL "bad" cholesterol. Peel and slice them into salads, add them to burritos, or mash as a sandwich spread.
BODY-BUILDING PROTEINS
Protein is required for muscle and tissue repair, blood sugar balance and proper immune function.
Eggs we buy are organic (laid by chickens that eat grains free of chemicals and that are not treated with hormones or antibiotics) and enriched with omega-3 fatty acids for cardiovascular health. We each have three to five eggs weekly -- boiled, poached or scrambled with cheese.
Poultry (skin removed) is typically lower in saturated fat than red meat and therefore is healthier for the cardiovascular system. We select poultry labeled "free range" (meaning the animals were not constantly caged and were not fed antibiotics). From the deli counter, we buy cooked, sliced turkey and chicken breast for sandwiches, opting for low-sodium, preservative-free brands. Favorite dinner entrées include turkey loaf (ground turkey can be substituted for beef and pork in meat loaf recipes) and pan-fried or broiled turkey burgers. We also love Angela's baked chicken breasts, seasoned with rosemary, lemon and poultry seasoning. We seldom barbecue meat or poultry because doing so creates cancer-causing compounds called heterocyclic amines (HCAs).
Wild ocean salmon (which we consider to be more healthful than farm-raised) we buy when it is in season, to bake or broil with olive oil and lemon. In addition to being low in calories and saturated fat, salmon is high in protein... omega-3s... vitamins B-3, B-6 and B-12 (cobalamin)... phosphorous... and magnesium. We avoid tuna -- including canned -- due to concerns about mercury contamination. However, canned ocean salmon packed in water is healthful, as are canned sardines -- though I confess that we do not enjoy the taste (or smell) of sardines.
Cheeses we enjoy in moderation include Colby and string cheese for snacks and shredded cheddar on burritos. Along with protein and calcium, cheese provides the amino acid tryptophan, which promotes thyroid function and positive moods.
cans, cartons & Jars
Packaged goods can be healthful, provided they don't have added preservatives, oils, sugars or salt.
Beans are a must for Mexican-style tostados. Their soluble fiber promotes proper cholesterol and blood sugar levels. Black beans are rich in antioxidant anthocyanins. Pinto beans have magnesium, potassium, manganese, copper and molybdenum, which help the liver with detoxification.
Almond milk is rich in potassium. Blue Diamond's unsweetened almond milk tastes great in cereal and scrambled eggs. A sweetened brand called Almond Breeze has 7 grams (g) of sugar per eight-ounce serving. We pour it over hot oatmeal and drink it as a snack. We also buy oat milk and rice milk. (We avoid drinking cow's milk because it can cause allergic and immune reactions and digestive distress.)
Peanut butter is a passion for our kids (and our dog, Blast). We buy pure peanut butter (in a glass container to avoid chemicals that may leach from plastics) that has no added sugar or partially hydrogenated fat. Peanut butter has heart-healthy monounsaturated fats, vitamin E, niacin, folate, manganese and resveratrol (the same antioxidant found in red wine). We also like almond butter, which is similar in nutrient content.
GREAT GRAINS & OTHER GOODIES
Selecting grains can be complicated for people who -- like my youngest son and me -- experience nasal congestion, bloating and diarrhea after consuming foods with gluten (a protein complex). Wheat, rye and barley all contain gluten.
Gluten-free grains include corn, amaranth, rice, buckwheat and quinoa. Of the gluten-free breads we have tried, those from Kinnikinnick Foods (877-503-4466, http://link.bls.bottomlinesecrets.com/h/KL2H/KLV5/QR/EU522) taste best. Pastas, cereals, pretzels, corn chips, tortillas and tostado shells also come in gluten-free varieties.
Cereals we select have no more than 3 g of sugar and provide at least 2 g to 3 g of fiber per serving. Favorites include Rice Crunch-Ems from Health Valley... Amazon Frosted Flakes from Nature's Path... and Kix or Cheerios from General Mills. We also get oatmeal -- a source of energy-sustaining complex carbohydrates, as well as manganese, selenium and silicon, which promote bone and cartilage health. The slow-cooking kind has the most fiber.
Seeds and nuts are on our list, too. I grind up two tablespoons of flaxseeds each morning, place them on my tongue, and wash them down with water. Flaxseeds provide fiber and essential fatty acids, and may combat cancer. Hemp seeds are high in protein and omega-3s. Almonds and walnuts are rich in antioxidants and omega-3s, respectively. Angela and I eat one-quarter cup daily, and we try to get our kids to eat a few.
Chips are big hits, especially bruschetta chips from Wild Oats (800-494-9453, http://link.bls.bottomlinesecrets.com/h/V2YA/KLV5/QR/EU522). Made with potatoes, tomatoes, basil and olive oil, they provide protein and fiber but no sugar or saturated fat.
Oils are important to good cooks (like Angela). Extra-virgin olive oil is what we use when cooking fish and chicken or roasting vegetables. Its monounsaturated fats promote cardiovascular health. To scramble eggs, we use organic canola oil, which contains vitamin E and omega-3s. Macadamia nut oil is best for stir-frying because it has a higher smoke point (the temperature at which a cooking oil breaks down and smokes, giving food an unpleasant taste).
Fun foods we enjoy without guilt include Rice Dream Bars (ice cream bars made from rice milk)... Newman's Own brand fig cookies... Ghirardelli semisweet chocolate chips... and SunSpire carob chips.
Eating healthfully comes at a premium. The price of organic foods is about 25% higher than the cost of foods that may have been grown using pesticides or made with unhealthful processing methods. We are happy to pay the price because our family's health is worth it. I suspect you feel the same way.
//////////////////////SUICD AS BANKRUPT-BIRATI MAN-56
//////////////////////To C- I became a pantheist because of a short article in the 'Utne' magazine,(some years ago), something about worshipping,respecting and loving Mother Nature, which I do. I love Mother Nature.for me, a field of daisies, sunflowers, any kind of flowers, asunrise/ sunset, a starlit sky, a full moon, a new moon, all thesebeautiful nature scenes are more 'holy', spiritual, lovely than themost beautiful cathedral/church/ temple in the world. I'm an atheist. Ibecame more so after watching a very compelling tv documentary ofRichard Dawkin's 'The God Delusion'. I was brought up with the Chinesereligion, which is a mixture of Confucianism, Taoism, Buddhism andancestral worship. On looking back now, it was an interestingexperience, praying to all those Chinese gods/goddesses, going to theChinese temples, etc.However, I don't practice any religion now, although my mother-in-lawand some of my sisters and friends tried, for many years, to convertme to be a ..... I was quite annoyed with them because they thinkthat what's good for them is good for me too. It's such a naive,tunnel vision kind of attitude. I don't dislike religious people. Irespect their beliefs, so long as they don't preach to me.One of my favourite Pantheist quotes:"..for nature gives to every time and season some beauty of its own.."Charles DickensI try to remember this cos I live in Toronto,Canada, and we've beenhaving lots of snow and cold lately. I love the spring and summer, andI find it harder and harder to endure the long, cold winter as I age!However, I will go with the flow and try to see the beauty of winter...G
//////////////////////Natural Selection
by David Ewing Duncan
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So You Want to Live Forever?
Nov 7 2007
Sirtris Pharmaceuticals is testing a fountain-of-youth pill in humans. You won't live forever, but it may slow aging and increase lifespan. So far, it's working.
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Illustration by: Leif Parsons
Momenta Pharmaceuticals Inc (MNTA)
Industry:Healthcare
Summary:A biotechnology company specializing in the detailed structural analysis of complex mixture drugs of the development of generic …
Primary executive:Steven B. Brugger, Divisional Senior VP/COO
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Alnylam Pharmaceuticals Inc (ALNY)
Industry:Healthcare
Summary:A biopharmaceutical company developing novel therapeutics based on RNA interference, which is a naturally occurring biological …
Primary executive:Barry E. Greene, COO
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Sirtris Pharmaceuticals, Incorporated (SIRT)
Industry:Healthcare
Summary:A biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with …
Primary executive:Garen G. Bohlin, Assistant Secretary/COO
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Dr.David Sinclair, Ph.D.
Industry:Healthcare
Biography:David Sinclair, Ph.D. has served as a member of our board of directors since 2004. Dr. Sinclair is a founder of Sirtris, …
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Dr.Christoph H. Westphal, M.D., Ph.D.
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When Spanish explorer Juan Ponce de Leon heard rumors of a fountain of youth from native Floridians in 1513, he was desperate enough to find it that he was willing to march in chain mail through fetid swamps infested with mosquitoes, alligators, and hostile locals. He never found it.Nearly five centuries later, the fabled longevity imbued by Florida's mythic fountains may be here for real. Not spewing from a magical spring with sweet-tasting waters, but in a pill designated SRT501.In Cambridge, Massachusetts, Sirtris Pharmaceuticals is testing such a pill in humans in a Food and Drug Administration-approved clinical trial. The tests began last spring with 85 volunteers; in August, the company announced that this medication designed to slow aging and bump up lifespan is working.
A caveat: It will take years of tests and trials to know if the drug will ultimately permit people to routinely live to over 100 years old, while fending off diseases of aging ranging from diabetes to cancer. You may remember hearing about the seemingly miraculous chemical that SRT501 is based on, called resveratrol. Sirtris co-founder and Harvard professor David Sinclair created a sensation when he announced in 2003 that this naturally occurring compound extends the lifespan of yeast.This might not have attracted much notice except that resveratrol is found in one of the most popular beverages in the world—red wine—a drink associated with rejuvenation even in the days of Ponce de Leon. According to Sinclair, the grape skins contain the substance, which is passed on during the winemaking process to vins rouges ranging from the humblest Gallo jug wine to the finest St. Emilion.SRT501 impacts a family of genes in humans and other organisms called "sirtuins," which seem to control a cornucopia of desirable functions in cells that lead
by David Ewing Duncan
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So You Want to Live Forever?
Nov 7 2007
Sirtris Pharmaceuticals is testing a fountain-of-youth pill in humans. You won't live forever, but it may slow aging and increase lifespan. So far, it's working.
Multimedia
The Ethanol-Industrial Complex
View Interactive Feature
Will anyone profit from the record corn harvest? See All Video & Multimedia
Recent Columns
F.D.A. On the Brink?
Dec 12 2007 1:00 AM EST
Optimists Conquer the World
Nov 28 2007 1:00 AM EST
So You Want to Live Forever?
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Illustration by: Leif Parsons
Momenta Pharmaceuticals Inc (MNTA)
Industry:Healthcare
Summary:A biotechnology company specializing in the detailed structural analysis of complex mixture drugs of the development of generic …
Primary executive:Steven B. Brugger, Divisional Senior VP/COO
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Alnylam Pharmaceuticals Inc (ALNY)
Industry:Healthcare
Summary:A biopharmaceutical company developing novel therapeutics based on RNA interference, which is a naturally occurring biological …
Primary executive:Barry E. Greene, COO
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Sirtris Pharmaceuticals, Incorporated (SIRT)
Industry:Healthcare
Summary:A biopharmaceutical company focused on discovering and developing proprietary, orally available, small molecule drugs with …
Primary executive:Garen G. Bohlin, Assistant Secretary/COO
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Dr.David Sinclair, Ph.D.
Industry:Healthcare
Biography:David Sinclair, Ph.D. has served as a member of our board of directors since 2004. Dr. Sinclair is a founder of Sirtris, …
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Dr.Christoph H. Westphal, M.D., Ph.D.
Industry:Healthcare
Biography:Christoph Westphal, M.D., Ph.D. is a founder of Sirtris and has served as CEO and Vice Chairman of our board of directors …
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When Spanish explorer Juan Ponce de Leon heard rumors of a fountain of youth from native Floridians in 1513, he was desperate enough to find it that he was willing to march in chain mail through fetid swamps infested with mosquitoes, alligators, and hostile locals. He never found it.Nearly five centuries later, the fabled longevity imbued by Florida's mythic fountains may be here for real. Not spewing from a magical spring with sweet-tasting waters, but in a pill designated SRT501.In Cambridge, Massachusetts, Sirtris Pharmaceuticals is testing such a pill in humans in a Food and Drug Administration-approved clinical trial. The tests began last spring with 85 volunteers; in August, the company announced that this medication designed to slow aging and bump up lifespan is working.
A caveat: It will take years of tests and trials to know if the drug will ultimately permit people to routinely live to over 100 years old, while fending off diseases of aging ranging from diabetes to cancer. You may remember hearing about the seemingly miraculous chemical that SRT501 is based on, called resveratrol. Sirtris co-founder and Harvard professor David Sinclair created a sensation when he announced in 2003 that this naturally occurring compound extends the lifespan of yeast.This might not have attracted much notice except that resveratrol is found in one of the most popular beverages in the world—red wine—a drink associated with rejuvenation even in the days of Ponce de Leon. According to Sinclair, the grape skins contain the substance, which is passed on during the winemaking process to vins rouges ranging from the humblest Gallo jug wine to the finest St. Emilion.SRT501 impacts a family of genes in humans and other organisms called "sirtuins," which seem to control a cornucopia of desirable functions in cells that lead
EAT RED GRAPES TO LIVE LONG
///////////////////////////Coffee and Asthma
Category: Harmful Coffee, Healthy Coffee
Here are some facts about the relationship between coffee and asthma. Regular coffee drinkers have about 1/3 less asthma symptoms than those of non-coffee drinkers according to a Harvard researcher who studied 20,000 people.For the past several years, many experts have touted how horrible coffees were for our health and that the drinking of caffeinated coffee should be immediately ceased. Recently, however, several studies have shown that caffeinated coffee can actually be extremely good for people. One of the groups of people who can reap health benefits from drinking caffeinated coffee is those people who suffer from asthma.
Category: Harmful Coffee, Healthy Coffee
Here are some facts about the relationship between coffee and asthma. Regular coffee drinkers have about 1/3 less asthma symptoms than those of non-coffee drinkers according to a Harvard researcher who studied 20,000 people.For the past several years, many experts have touted how horrible coffees were for our health and that the drinking of caffeinated coffee should be immediately ceased. Recently, however, several studies have shown that caffeinated coffee can actually be extremely good for people. One of the groups of people who can reap health benefits from drinking caffeinated coffee is those people who suffer from asthma.
///////////////////////Chapter VII: The Yoga of the Division of WisdomVII.30. SAADHIBHOOTAADHIDAIVAM MAAM SAADHIYAJNAM CHA YE VIDUH; PRAYAANAKAALE'PI CHA MAAM TE VIDUR YUKTACHETASAH. (Krishna speaking to Arjuna)Those who know Me with the Adhibhuta (pertaining to the elements), the Adhidaiva (pertaining to the gods), and Adhiyajna (pertaining to the sacrifice), know Me even at the time of death, steadfast in mind. COMMENTARY: They who are steadfast in mind, who have taken refuge in Me, who know Me as knowledge of elements on the physical plane, as knowledge of gods on the celestial or mental plane, as knowledge of sacrifice in the realm of sacrifice,-they are not affected by death.
////////////////////////Blood 'biopsy' may provide information to guide treatment planning, monitor responsehttp://www.curingdeath.com/research/Microchip-based_device_can_detect_rare_tumor_cells_in_bloodstream.aspHigh-Fat, High-Carb Meal More Destructive to the ObeseIncrease in already high free radicals significantly raises heart-attack riskhttp://www.curingdeath.com/research/High-Fat_High-Carb_Meal_More_Destructive_to_the_Obese.aspNew insights into deadly heart rhythm disorderBetter ways to identify people at risk for ventricular fibrillation could arise from U-M/SUNY group's work showing universal law of electrical turbulence in the hearthttp://www.curingdeath.com/research/New_insights_into_deadly_heart_rhythm_disorder.asp
////////////////////////Mutant Gene Identified as Villain in Hardening of the ArteriesA genetic mutation expands lesions in the aorta and promotes coronary atherosclerosis, more commonly known as hardening of the arteries, according to a study by Yale School of Medicine in Cell Metabolism.http://www.curingdeath.com/research/Mutant_Gene_Identified_as_Villain_in_Hardening_of_the_Arteries.asp
///////////////////Firefly genes allow testing of new therapy against lymphomaResearchers here have figured out a way to use a firefly gene to let them see just how effective a new drug combination actually is against some forms of cancer and its serious complication.http://www.curingdeath.com/research/Firefly_genes_allow_testing_of_new_therapy_against_lymphoma.asp
//////////////////////
Baby units 'face staff shortages'Baby units in England refuse new admissions once a week on average because of staff shortages, a report says.
Baby units 'face staff shortages'Baby units in England refuse new admissions once a week on average because of staff shortages, a report says.
///////////////////////
Why Deep-Diving Mammals Don't Black Out
By Jeanna Bryner, LiveScience Staff Writer
posted: 18 December 2007 09:53 pm ET
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Some seals and dolphins can hold their breath underwater for a cheek-popping hour or more without passing out from lack of oxygen.
Definitely don't try this at home. Humans can't make it more than a few minutes without breathing (at least without some sci-fi device).
The secret to the superhero animal feat is elevated levels of special oxygen-carrying proteins found in their brains, a new study reveals. But the research leaves puzzles.
Scientists have long wondered why marine mammals, such as dolphins, whales, Weddell seals and sea otters, are so tolerant of such low oxygen conditions. The simplest explanation had been that they evolved adaptations to boost oxygen delivery to the brain. But studies have shown that the oxygen levels in their blood vessels plummeted within minutes of dipping beneath the water's surface.
"The kinds of levels we were seeing in arterial blood would have caused us to black out under water," said lead study author Terrie Williams, professor of ecology and evolutionary biology at the University of California, Santa Cruz.
The research will be published in the Dec. 18 issue of the journal Proceedings of the Royal Society B.
Diving secret
Williams and her colleagues focused on two newly discovered proteins called neuroglobin and cytoglobin. They are similar to hemoglobin, an iron-containing molecule that carries oxygen in blood and circulates throughout the body and brain, but neuroglobins and cytoglobins (grouped together as brain globins) reside in brain tissues.
The scientists compared the amounts of hemoglobin and the brain globins in 16 mammal species, including land animals such as a bobcat and a mountain lion, shallow swimmers such as the bottlenose dolphin and California sea lion, and deep divers such as the pilot whale and Risso's dolphin.
The results were not clear-cut.
On average, the brains of marine mammals had more hemoglobin and brain globins than those of land animals, suggesting it's these proteins that keep the divers alive and alert during deep dives. The shallow-swimming and highly active dolphins, sea lions and sea otters had higher amounts of the brain globins than did the deep-diving whales. Williams suggests that the agile swimmers need to shuttle oxygen quickly to the brain and so they rely on the brain globins rather than the hemoglobin. The more hemoglobin in the blood, the more viscous the blood becomes, making transport to the brain slower.
And then there was the bobcat. Unlike the dog-related species, including foxes and coyotes, bobcat tissues showed high amounts of the brain globins. "Maybe it's not just breath-holding that stimulates these globins, but high levels of activity, such as sprinting," Williams said.
Human aging
The finding could shed light on strokes and aging in humans. For instance, boosting globin production in humans could potentially lessen brain damage due to disease and aging.
"If you're a wild animal you don't get the option of having a stroke. If you have a stroke, you're dead," Williams told LiveScience. "[The diving mammals] might be the group to look toward, because evolution and selective pressures would push them toward better protection."
Bowhead whales live 200-plus years, more than double the typical human lifetime. Williams asks, "What if you could do something that would keep your brain active for twice as long?"
Why Deep-Diving Mammals Don't Black Out
By Jeanna Bryner, LiveScience Staff Writer
posted: 18 December 2007 09:53 pm ET
Share this story
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Some seals and dolphins can hold their breath underwater for a cheek-popping hour or more without passing out from lack of oxygen.
Definitely don't try this at home. Humans can't make it more than a few minutes without breathing (at least without some sci-fi device).
The secret to the superhero animal feat is elevated levels of special oxygen-carrying proteins found in their brains, a new study reveals. But the research leaves puzzles.
Scientists have long wondered why marine mammals, such as dolphins, whales, Weddell seals and sea otters, are so tolerant of such low oxygen conditions. The simplest explanation had been that they evolved adaptations to boost oxygen delivery to the brain. But studies have shown that the oxygen levels in their blood vessels plummeted within minutes of dipping beneath the water's surface.
"The kinds of levels we were seeing in arterial blood would have caused us to black out under water," said lead study author Terrie Williams, professor of ecology and evolutionary biology at the University of California, Santa Cruz.
The research will be published in the Dec. 18 issue of the journal Proceedings of the Royal Society B.
Diving secret
Williams and her colleagues focused on two newly discovered proteins called neuroglobin and cytoglobin. They are similar to hemoglobin, an iron-containing molecule that carries oxygen in blood and circulates throughout the body and brain, but neuroglobins and cytoglobins (grouped together as brain globins) reside in brain tissues.
The scientists compared the amounts of hemoglobin and the brain globins in 16 mammal species, including land animals such as a bobcat and a mountain lion, shallow swimmers such as the bottlenose dolphin and California sea lion, and deep divers such as the pilot whale and Risso's dolphin.
The results were not clear-cut.
On average, the brains of marine mammals had more hemoglobin and brain globins than those of land animals, suggesting it's these proteins that keep the divers alive and alert during deep dives. The shallow-swimming and highly active dolphins, sea lions and sea otters had higher amounts of the brain globins than did the deep-diving whales. Williams suggests that the agile swimmers need to shuttle oxygen quickly to the brain and so they rely on the brain globins rather than the hemoglobin. The more hemoglobin in the blood, the more viscous the blood becomes, making transport to the brain slower.
And then there was the bobcat. Unlike the dog-related species, including foxes and coyotes, bobcat tissues showed high amounts of the brain globins. "Maybe it's not just breath-holding that stimulates these globins, but high levels of activity, such as sprinting," Williams said.
Human aging
The finding could shed light on strokes and aging in humans. For instance, boosting globin production in humans could potentially lessen brain damage due to disease and aging.
"If you're a wild animal you don't get the option of having a stroke. If you have a stroke, you're dead," Williams told LiveScience. "[The diving mammals] might be the group to look toward, because evolution and selective pressures would push them toward better protection."
Bowhead whales live 200-plus years, more than double the typical human lifetime. Williams asks, "What if you could do something that would keep your brain active for twice as long?"
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