Before introduction of Bexsero, there were convincingly low levels of side effects in extremely premature babies following routine immunisation. After introduction of Bexsero, 33% (6/18) became unwell within 48 hours of vaccination and 28% (5/18) needed escalation in respiratory support. Eleven per cent (2/18) needed rescue ventilation following Bexsero vaccination. We also observed a more sustained C reactive protein response on unwell babies after Bexsero vaccination in Period 2, which influenced our decision to treat them with antibiotics for 5 days. Interestingly, the median gestational age of babies who became unwell (33%) following Bexsero administration was 25 weeks.
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