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FEAR WE GO AGAIN
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PSYD Prolonged loneliness can lead to type-2 diabetes, new research suggests
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CR
Pulmonary hypertension related to hereditary folate malabsorption in an infant
We are not an Ego - (3865)
We can do that at times: see a person as an ego. But there is a mistake in our way of thinking.
Such a way of thinking actually does do not us any good inside of ourselves.
A person may have that ego but they are not that ego. Pretty basic truth, but we often find ourselves making that mistake. Especially when we are scared of a person we think of them as only being an ugly ego of anger.
The thought we have about a person is not the person. The photo on the fridge of a person is not the person either. A person is not the Negative or positive flavour that is evoked in us when we think of them either. A person is a whole complete living tree of life, an alive real spark of the Absolute, just as real a person as we are.
Polysomnographic characteristics and sleep‐disordered breathing in Schaaf‐Yang syndrome
Abstract
Introduction
Schaaf‐Yang syndrome (SYS) is a genetic disorder caused by truncating variants in the MAGEL2 gene located in the maternally imprinted Prader‐Willi syndrome (PWS) region at 15q11‐13. The SYS phenotype shares features with PWS, a syndrome with known high incidence of sleep disorders. However, the spectrum of sleep‐disorders in SYS has not been described.
Methods
We performed a retrospective analysis of polysomnograms from 22 patients in an international SYS cohort. Sleep characteristics for individuals with the common c.1996dupC variant (n = 10) were compared to other truncating variants (n = 11).
Results
We collected 33 sleep study reports from 22 patients, ages 2 months – 18.5 years (mean 6.5 years). Mean sleep efficiency was 70.5% (range 45%–93%) with arousal index 14.1/h (1.2–45/h). The mean apnea‐hypopnea index (AHI) was 19.1/h (0.9–49/h) with mean obstructive AHI (oAHI) of 16.3/h (0.6–49/h). Mean central apnea index was 2.8/h (0–14/h). Mean oxygen desaturation index was 20.8/h (range 0–85/hr). Obstructive sleep apnea (OSA) was diagnosed in 81%, and 62% had moderate or severe OSA. Elevated central apnea index occurred in 9.5%. Comparison by genotype groups and age did not reveal any difference in OSA findings. Periodic limb movement index (PLMI) was elevated in 4/15 (26%).
Conclusion
OSA is frequently identified on polysomnography in patients with SYS. The mean PLMI is elevated compared to normative data. Patients with SYS should have routine polysomnography screening due to high risk of sleep disorders.
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Respiratory Severity Score Greater than or Equal to 2 at Birth is Associated with Increased Risk of Mortality in Infants with Birthweights Less Than or Equal to 1,250 grams
Financial Disclosure:: The authors have no financial relationships relevant to this article to disclose.
Funding Source:: None.
Clinical Trials Registration:: Not Applicable
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ppul.25069
Abstract
Objective
Respiratory Severity Score (RSS), the product of Mean Airway Pressure (MAP) and Fraction of Inspired Oxygen (FiO2) may estimate severity of neonatal lung disease. We aimed to determine if RSS on the first day of life is associated with mortality and/or comorbidities in infants born less than or equal to 1,250 grams.
Methods
Data were extracted from the NYS Perinatal Data System for premature inborn infants from 2006‐2016 born between 400‐1,250 grams (N=730). RSS was divided into three categories: less than 2 (Low, n=310), 2‐5 (Moderate, n=265), greater than 5 (High, n=155). The primary outcome was mortality. Logistic regression determined associations with composite outcomes of death or Respiratory Morbidity [respiratory support after 36 weeks post menstrual age (PMA)], death or Neurologic Morbidity [periventricular leukomalacia (PVL) or high grade intraventricular hemorrhage (IVH)], and Death/Severe Morbidity [death or Neurologic Morbidity or Respiratory Morbidity or stage ≥III retinopathy of prematurity (ROP) or necrotizing enterocolitis (NEC)] by RSS category.
Results
Birthweight and gestational age were lower with increasing RSS category (p<0.001 for both). Mode of delivery, antenatal steroids, and maternal age did not differ by RSS. In adjusted analyses, there were increased odds of mortality in infants with Moderate RSS (OR [95% Confidence Intervals] 3.1 (1.7‐5.4) and High 4.5 (2.5‐8.2). These groups had higher odds of death or Respiratory Morbidity, death or Neurologic Morbidity, and Death/Severe Morbidity.
Conclusion
Higher RSS (greater than or equal to 2) is associated with increased risk of mortality and morbidities in infants born less than or equal to1,250 grams.
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ENTROPY ALWAYS INCREASES X 2LOTD X ARROW OF TIME
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ARROW OF TIME X STARS WILL NOT SHINE FOREVER
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2LOTD X AOT X EBWDOD
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