hypertonic saline outperformed mannitol in terms of lowering ICP.

hypertonic saline outperformed mannitol in terms of lowering ICP.

 In SAH patients without elevated ICP, hypertonic saline seems to lower ICP and increase CPP as compare to NS.

STDY-

Both mannitol and 7.5% saline resulted in similar reductions in ICP.

Routine prehospital administration of hypertonic saline to traumatic brain injury patients does not results in improved clinical outcomes.

For now, either hypertonic saline or mannitol is a reasonable choice if you need to treat an elevated intracranial pressure. When we should be treating elevated ICP and whether such treatment results in any patient oriented benefit is still a mystery.