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p kzn lipid profile x eczema
Association of serum lipid parameters with the SCORAD index and onset of atopic dermatitis in children
Background
The association between dyslipidemia and atopic dermatitis in children is unclear. This study investigated the association between dyslipidemia and atopic dermatitis in children by analysis of disease onset, risk factors, and disease severity.
Methods
Subset I examined 7‐year‐old children in elementary school (n = 248), and Subset II was a retrospective long‐term follow‐up hospital‐based study (n = 52 725) conducted from 1986 to 2016 that used propensity score matching. In the Subset I study, total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and triglycerides (TG) were determined, and the SCORing Atopic Dermatitis (SCORAD) index was determined. In the Subset II study, the time of atopic dermatitis onset was determined for asymptomatic subjects whose TC levels were below or above 170 mg/dL.
Results
Our Subset I study indicated that children with atopic dermatitis (n = 69, 27.8%) had significantly higher levels of TC and TG, and that the SCORAD index had significant associations with high levels of TC and TG, and a low level of HDL‐C. Our Subset II study (1722 with high TC and 6735 with normal TC after propensity score matching) indicated the high TC group had a greater hazard ratio (HR) for the onset of atopic dermatitis (consensus‐based HR: 2.47; 95% CI: 1.23, 5.06, P = .012) during 5 years.
Conclusion
An abnormal blood lipid profile in children is associated with the presence of atopic dermatitis and the SCORAD index. The risk of atopic dermatitis onset was significantly greater with high levels of TC.
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p kxn asthma x eosinophils
Blood Eosinophil Count as Predictor of Asthma Exacerbation. A Meta‐analysis
Background
Evidence about the association of high blood eosinophil count with asthma exacerbation is inconsistent and unclear. The objective of this meta‐analysis is to determine whether elevated blood eosinophils count predicts asthma exacerbation.
Methods
We searched MEDLINE, EMBASE, and additional databases, without any language restriction. We also checked the reference lists of the included studies and of relevant systematic reviews. The main outcome was the occurrence of asthma exacerbation. We calculated global pooled Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) and performed predefined subgroup analyses. We appraised the quality of the studies using Newcastle‐Ottawa Scale, examined the heterogeneity between studies, assessed publication bias and carried out sensitivity analyses.
Results
Among 1567 retrieved publications, 23 observational studies comprising 155,772 participants met the inclusion criteria. High blood eosinophil count was associated with higher odds of asthma exacerbation [OR: 1.31 (95%CI: 1.16, 1.49)], specifically with asthma‐related outpatient visits [OR: 1.46 (95%CI: 1.25, 1.70)] and emergency department visits [OR: 1.63 (95%CI: 1.29, 2.07)]. A significant association was observed starting from an eosinophils’ cut‐off value of 200 cells/μl. The association was observed for cohort studies [OR: 1.30 (95%CI: 1.13, 1.49)], North‐American studies [OR: 1.43 (95%CI: 1.31, 1.57)], Asian populations [OR: 1.67 (95%CI: 1.34, 2.08)] children [OR: 1.38 (95%CI: 1.22, 1.56)], and studies that adjusted for inhaled corticosteroids therapy [OR: 1.42 (95%CI: 1.28, 1.56)].
Conclusions
Blood eosinophil counts ≥ 200 cells/µl are associated with asthma exacerbation. Blood eosinophil count is a modifiable factor that could be addressed in asthma management strategies.
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Kawasaki Disease in a 3-Month-Old Infant
How to Remain Vigilant?
Kawasaki disease is an acute vasculitis occurring between 6 months and 5 years old. Patients younger than 6 months have mostly incomplete form. This clinical symptoms lead to confusion and delayed diagnosis.
Case Report
We developed the diagnostic difficulties with a 3-month-old infant. At the beginning, his incomplete presentation misled pediatricians.
Conclusions
We highlight the possibilities of Kawasaki disease in infants younger than 6 months. Indeed, every diagnostic delay increases cardiovascular risk. Nonetheless, in our case, treatment was prescribed in the first 5 days, and the patient developed aneurysms.
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covid misc- p kzn
The exact pathogenesis of MIS-C is as yet unknown. However, it has been suggested that part of the SARS-CoV-2 viral spike protein may resemble a superantigen that could drive the development of MIS-C and trigger cytokine storms in adults.6 Specifically, polymorphic residues in the viral spike protein, including A831V and D839Y/N/E, which are predicted to enhance binding affinity to the T-cell receptor, have been observed in lineages circulating in Europe and North America, where most MIS-C cases have been described. In addition, the 614G spike protein polymorphism may be associated with increased transmission and altered SARS-CoV-2 biology.7 Phylogenetic comparisons of SARS-CoV-2 viral sequences from patients with MIS-C and patients without MIS-C are necessary to identify the significance of viral polymorphisms in the etiology of MIS-C.
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Give light, and the darkness will disappear of itself.- Desiderius Erasmus
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Hope is a flame that we nurture within our hearts. It may be sparked by someone else—by the encouraging words of a friend, relative, or mentor—but it must be fanned and kept burning through our own determination.
—Daisaku Ikeda, “On Hardship & Hope”
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B MIND X CLIMATE CRSS
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