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In systemic lupus erythematosus (SLE), the behavior of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can vary:
1. CRP (C-reactive protein):
- CRP is typically a marker for acute inflammation and rises in response to infection or injury.
- In SLE, CRP levels may not be significantly elevated during disease flares, even when inflammation is present. This is because SLE-associated inflammation tends to be more immune-complex driven rather than caused by the type of acute-phase response that triggers high CRP.
- However, if a secondary infection or other inflammatory conditions (like serositis or arthritis) occur, CRP levels can rise sharply.
2. ESR (Erythrocyte Sedimentation Rate):
- ESR tends to be elevated during active disease in SLE and can correlate with disease activity.
- It is considered a more reliable marker for lupus activity than CRP, and high ESR levels are common during flares of systemic inflammation or increased immune system activity in SLE.
- Like CRP, ESR can also rise due to infections or other inflammatory conditions, but its elevation is more commonly observed in lupus flares compared to CRP.
Summary:
- CRP: May remain normal or mildly elevated during SLE flares, but can rise significantly in infections or co-existing conditions.
- ESR: Typically elevated during active SLE and correlates more with lupus disease activity.
ESR is often considered a better indicator of SLE flares than CRP.
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sle crp normal
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