P KZN RENAL SCARRING X UTI X VIT D

Vitamin D Deficiency as a Risk Factor for Renal Scarring in Recurrent Urinary Tract Infections

Serra Sürmeli Döven 

 

Semra Erdoğan

First published: 20 July 2020

 

https://doi.org/10.1111/ped.14397

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ped.14397

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Abstract

Background

Renal scarring is a serious complication in Recurrent Urinary Tract Infections (UTIs), and Vitamin D deficiency has also been reported to be a risk factor for UTIs, although to date, no association between vitamin D deficiency and renal scarring has yet been identified. In the present study, it was investigated whether vitamin D deficiency may be a risk factor for renal scarring in patients with recurrent UTIs.

Methods

The study included patients between the age of 1 and 18 years, who were admitted to the Pediatric Nephrology Department of the center between 01.11.2018 and 01.11.2019 and who were diagnosed with recurrent UTIs. The medical records of the patients were reviewed for the collection of demographic data, vitamin D levels, ultrasonography results and scintigraphic investigations with 99m‐technetium dimercaptosuccinic acid (99mTc‐DMSA). The patients were divided into two groups, as those with and without renal scarring, diagnosed via 99mTc‐DMSA. The vitamin D levels and other parameters of the two groups were compared.

Results

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Conclusions

Vitamin D deficiency is found to be a risk factor for renal scarring in patients with recurrent UTIs. Vitamin D treatment may contribute to the prevention of renal scarring in patients with recurrent UTI.