NEDICINE

 MEDICINE 1.0 - HIPPOCRATES

MED 2.0- GERM THEORY OF DISEASE 

MED 3.0 - 

This graph shows how little real mortality rates have improved since 1900, once you remove the top eight contagious/infectious diseases, which were largely controlled by the advent of antibiotics in the early twentieth century.

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 largest shift is that where Medicine 2.0 focuses largely on lifespan, and is almost entirely geared toward staving off death, Medicine 3.0 pays far more attention to maintaining healthspan, the quality of life.

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To succeed in life, you need two things: ignorance and confidence. – Mark Twain

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Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat. —Sun Tzu

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Positive Feelings Related to Work

 

These are always felt as pleasant and include such feelings as joy, happiness and security. They instigate a process of thinking and ideation that is exemplified by the thoughts "I can" and "We can," regardless of the event, situation, or problem in which the person is involved.

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Take 100 people who resolve to diet on New Year’s Eve and by January 19 most will have abandoned the effort

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blue zones-  The residents of these hotspots were mostly eating a whole-food, plant-based diet, and instead of trotting off to the gym, they moved naturally every 20 minutes or so. Daily rituals like prayer, ancestor veneration, and napping also helped them downshift and lower stress-induced inflammation. 

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 Fact is, the current maximum life expectancy for people in the first world (i.e., those not beleaguered by infectious diseases such as malaria, dysentery, and cholera) is about 93 years—less for men and a little longer for women. But in the United States, life expectancy is only 77. We are leaving 16 years on the table. “

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margl decade v bonus decade 

we live longer, and we live better for longer. We outlive our life expectancy, and we also exceed society’s expectations of what our later life is supposed to look like. Instead of a lousy Marginal Decade, we get to enjoy what feels more like a “Bonus Decade”—or decades—when we are thriving in every dimension. This is our objective: to delay death, and to get the most out of our extra years. The rest of our lives becomes a time to relish rather than to dread.

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OST 

OBJECTIVE > STRATEGY> TACTICS 

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 The best science out there says that what you eat matters, but the first-order term is how much you eat: how many calories you take into your body

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 Mike Tyson once put it, “Everyone has a plan until they get punched in the mouth.”

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FRUIT SALAD SIMILIE

we don’t have a unified consciousness; what we experience is a time series of discrete events in which one of the five sense consciousness always alternates with mind consciousness.

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KGXE 

a 2007 study found that older people who were put on a regular exercise program shifted to a more youthful pattern of gene expression after six months. This suggests that genetics and environment both play a role in longevity and that it may be possible to implement interventions that replicate at least some of the centenarians’ good genetic luck

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Wisdom is what's left after we've run out of personal opinions."

CULLEN HIGHTOWER a ‘Because all things change, nothing disappears.’ Zen Graffiti a Blueberries can reduce inflammation through their antioxidant effects and reduce the accumulation of cholesterol in blood vessels by affecting the metabolism and transport of cholesterol A a RAPAMYCIN X MTOR . Ultimately, he and others discovered that rapamycin acted directly on a very important intracellular protein complex called mTOR (pronounced “em-tor”), for “mechanistic target of rapamycin A a In my theatrical framework, there is a three-tiered structure of illusion: subject, awareness, object. The existence of "awareness of awareness" reveals that there is no subject of "awareness" at all. A But if we’re talking about preventing the diseases of aging, which kill 80 percent of us, then it’s certainly worth having a serious conversation about what level of risk is and isn’t acceptable in order to achieve that goal. Part of my aim in writing this book is to move that conversation forward. a A  Avoidable human misery is more often caused not so much by stupidity as by ignorance, particularly our ignorance about ourselves. —Carl Sagan a As type 2 diabetes emerged, beginning in the early 1700s, it was at first largely a disease of the superelite, popes and artists and wealthy merchants and nobles who could afford this newly fashionable luxury food known as sugar. The composer Johann Sebastian Bach is thought to have been afflicted, among other notable personages. It also overlapped with gout, a more commonly recognized complaint of the decadent upper classes. This, as we’ll soon see, was not a coincidence A a FITBIT BACTERIA  Ninety-five percent of the wristbands were contaminated. Rubber and plastic were the main culprits because of their porous and rough texture; gold, silver and metal bands showed very little bacteria. Staphylococcus was found in 85 percent of the wristbands. Staph is the leading cause of skin and soft tissue infections such as abscesses (boils), furuncles and cellulitis. Gym-goers’ wristbands showed the highest staphylococcal counts. E. coli was found on 60 percent of the wristbands. E-coli is responsible for diarrhea, stomach cramps and occasionally fever. Pseudomonas were found in 30 percent of the wristbands. This type of bacteria commonly causes a mild skin rash, eye or ear infection. The infection may become more serious in those who are immune-compromised. A The risk of a wrong decision is preferable to the terror of indecision." - Maimonides A But the first thing I look for,  of metabolic disorder, is elevated insulin. As we’ve seen, the body’s first response to incipient insulin resistance is to produce more insulin. Think back to our analogy with the balloon: as it gets harder to get air (glucose) into the balloon (the cell), we have to blow harder and harder (i.e., produce more insulin). At first, this appears to be successful: the body is still able to maintain glucose homeostasis, a steady blood glucose level. But insulin, especially postprandial insulin, is already on the rise.  A Typically, “normal” means between the 2.5th and 97.5th percentiles, a very wide range. A  There is some risk involved in action, there always is. But there is far more risk in failure to act. —Harry S. Truman A Globally, heart disease and stroke (or cerebrovascular disease), which I lump together under the single heading of atherosclerotic cardiovascular disease, or ASCVD, represent the leading cause of death, killing an estimated 2,300 people every day in the United States, according to the CDC—more than any other cause, including cancer. It’s not just men who are at risk: American women are up to ten times more likely to die from atherosclerotic disease than from breast cancer (not a typo: one in three versus one in thirty). But pink ribbons for breast cancer far outnumber the American Heart Association’s red ribbons for awareness of heart disease among women. A In spite of how well we understand atherosclerotic disease and its progression, and how many tools we have to prevent it, it still kills more people than cancer in the United States each year, many of them completely out of the blue. We’re losing the war. I don’t claim to have all the answers, but I think this is at least partly due to the fact that we still have some major blind spots in our understanding of what truly drives our risk for the disease, how it develops, and most of all when we need to act to counter its momentum a  Fully half of all major adverse cardiovascular events in men (and a third of those in women), such as heart attack, stroke, or any procedure involving a stent or a graft, occur before the age of sixty-five. In men, one-quarter of all events occur before age fifty-four. a ATHSCLRTC DIS OF COR A - 23 YR OLD  CORE AND FOAM CELLS -ATHSCL  A    whether they are like Anahad (with one prominent risk factor) or like me (lots of smaller risk factors). Our first order of business is to reduce the burden of apoB particles, primarily LDLs but also VLDLs, which can be dangerous in their own right. And do so dramatically, not marginally or incrementally. We want it as low as possible, sooner rather than later. We must also pay attention to other markers of risk, notably those associated with metabolic health, such as insulin, visceral fat, and homocysteine, an amino acid that in high concentrations[*7] is strongly associated with increased risk of heart attack, stroke, and dementia A If you can't explain it simply, you don't understand it well enough." - Albert Einstein a Sniderman and colleagues’ analysis found that looking at a thirty-year time frame rather than the standard ten years and taking aggressive precautionary measures early— like beginning statin treatment earlier in certain patients—could prevent hundreds of thousands more cardiac events, and by implication could save many lives a You may have to fight a battle more than once to win it. —Margaret Thatcher a A When we're conscious with every step, the making of the tea is not a means to an end, it becomes a work of art." —Eckhart Tolle, Doorways into Presence a The side effects of chemo might seem at the outset to be a fair trade for a “chance for a few more useful years,” as the late author Christopher Hitchens noted in his cancer memoir Mortality. But as his treatment for metastatic esophageal cancer dragged on, he changed his mind. “I lay for days on end, trying in vain to postpone the moment when I would have to swallow. Every time I did swallow, a hellish tide of pain would flow up my throat, culminating in what felt like a mule kick in the small of my back….And then I had an unprompted rogue thought: If I had been told about all this in advance, would I have opted for the treatment?” A In the 1990s and early 2000s, as rates of smoking and smoking-related cancers declined, a new threat emerged to take the place of tobacco smoke. Obesity and type 2 diabetes were snowballing into national and then global epidemics, and they seemed to be driving increased risk for many types of cancers, including esophageal, liver, and pancreatic cancer. The American Cancer Society reports that excess weight is a leading risk factor for both cancer cases and deaths, second only to smoking a  At the still point of the turning world. Neither flesh nor fleshless; Neither from nor towards; at the still point, there the dance is, But neither arrest nor movement. And do not call it fixity, Where past and future are gathered. Neither movement from nor towards, Neither ascent nor decline. Except for the point, the still point, There would be no dance, and there is only the dance.― T.S. Eliot  A The signal event here (again) appears to be a drop in energy delivery to the brain, similar to what is seen in the onset of vascular dementia. Brain imaging studies reveal lower brain glucose metabolism, decades before the onset of other symptoms of vascular dementia. Intriguingly, this reduction appears to be especially dramatic in brain regions that are also affected in Alzheimer’s disease, including the parietal lobe, which is important for processing and integrating sensory information; and the hippocampus of the temporal lobe, which is critical to memory. Just like reduced blood flow, reduced glucose metabolism essentially starves these neurons of energy, provoking a cascade of responses that include inflammation, increased oxidative stress, mitochondrial dysfunction—and ultimately neurodegeneration itself. A Absorb what is useful, discard what is useless, and add what is specifically your own. —Bruce Lee a  "In meditation, it’s not the technique that’s important. It’s the attitude—the attitude of ease, and openness."   —ADYASHANTI A I never won a fight in the ring; I always won in preparation. —Muhammad Ali a