According to the UK Health Security Agency (UKHSA) guidelines, a 6-year-old child with acute lymphoblastic leukaemia (ALL), who is varicella-zoster virus (VZV) antibody negative and has been exposed to chickenpox within the last 48 hours, should receive post-exposure prophylaxis (PEP) with oral aciclovir.
Key Points:
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Eligibility for PEP: Immunosuppressed individuals, such as children undergoing treatment for ALL, are at increased risk of severe varicella infection. PEP is recommended for those who have had significant exposure to chickenpox and are VZV antibody negative. (GOV.UK)
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Timing of Antiviral Therapy: Oral aciclovir should be initiated from day 7 to day 14 after exposure. If the child presents after day 7 of exposure, a 7-day course of antivirals can be started as soon as possible, up to day 14 post-exposure. (GOV.UK)
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Dosage: The recommended dosage of oral aciclovir for children aged 2 to 12 years is 20 mg/kg (maximum 800 mg) four times daily for 7 days. Dosage should be adjusted based on renal function and under specialist guidance.
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Alternative to VZIG: Varicella zoster immunoglobulin (VZIG) is no longer routinely available in the UK for most groups. It is reserved for neonates exposed within one week of delivery or individuals for whom oral antivirals are contraindicated. (GOV.UK, Patient)
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Monitoring: Despite prophylaxis, the child may still develop chickenpox. Caregivers should be advised to monitor for symptoms and seek medical attention if signs of infection appear.
For detailed guidance, please refer to the UKHSA's Guidelines on post-exposure prophylaxis for varicella or shingles.(GOV.UK)
It is essential to consult with the child's healthcare provider to initiate appropriate prophylactic treatment and ensure close monitoring during the incubation period.
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Knowing Iswara, jiva and the universe to be Brahman means that Brahman is the
adhishtanam and since Iswara, jiva and the universe are products of Maya (i.e.
mithya), they are not different entities. Swetasvatara 1.7 says that the three are
supported by Parabrahman.
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the effulgent Sakshi as the all pervading Brahman, who, in the form of
Iswara, is the creator of the universe, becomes free from punya papa, becomes
taintless and attains total identity with Brahman.‖ Mundaka Upanishad II.i.10 –
―He who knows this supremely immortal Brahman as existing in the heart
destroys, here, the knot of ignorance.‖ Brhadaranyaka Upanishad IV.iii.21
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