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Here is a concise, accurate historical timeline of when IV fluids were first used on humans in medical history — no web search needed, this is well-established historical knowledge:
History of IV Fluids in Humans
✔ 1650s – First IV experiments (animals, then humans)
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Sir Christopher Wren (yes, the architect) and colleagues performed the first intravenous injections in 1656, using animal bladders and quills.
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These early experiments included injecting substances into dogs; some accounts indicate that human experiments followed soon after, though extremely crude and dangerous.
✔ 1660s–1670s – First human IV attempts
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Early physicians in Europe (notably Johann Daniel Major and Johannes Elsholtz) attempted direct IV infusions in humans, typically with drugs or other substances.
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These attempts were primitive, often fatal, and the practice largely disappeared for over a century.
✔ 1831–1832 – Modern IV fluid therapy begins
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Dr. Thomas Latta (Scotland) performed the first successful therapeutic IV saline infusions on humans during the 1830s cholera epidemic.
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He infused saline solution into severely dehydrated cholera patients.
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Many revived almost immediately — this is considered the birth of modern IV fluid therapy.
✔ Late 1800s – IV techniques improve
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Adoption was slow, but by the late 19th century:
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Sterilization (Lister)
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Better needles
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Physiologic saline formulas
made IV therapy safer and more consistent.
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✔ 20th century – Standard medical practice
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IV fluids (saline, glucose, blood products, electrolytes) became routine hospital therapy by the early–mid 1900s.
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Development of plastic IV bags (1960s) made modern IV therapy ubiquitous.
Summary Answer
IV fluids were first used on humans in the 1660s, in primitive and dangerous experiments.
Modern, successful IV fluid therapy began in 1831–1832 with Dr. Thomas Latta’s lifesaving saline infusions for cholera.
If you’d like, I can also provide:
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a full historical timeline,
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a short 5-bullet answer, or
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how IV fluids evolved into the modern formulations used today.
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