Monday, 20 October 2025

EOL Psyd

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Here’s a more detailed protocol table for psychedelic-assisted end-of-life therapy, integrating session timelines, preparation, music/ritual guidance, and integration techniques. This is based on clinical research and therapeutic practice:

Substance

Dose / Administration

Preparation

Dosing Session

Support & Environment

Integration

Typical Timeline

Psilocybin

20–30 mg oral (~0.3–0.5 mg/kg)

1–2 preparatory sessions (1–2 hours each), discuss fears, intentions, prior psychological assessment

6–8 hours; patient lies down with eyeshades, music playlist, optional guided imagery

2 therapists present; safe, comfortable room; supportive communication

1–2 post-session integration sessions (1–2 hours each) to discuss insights, fears, and end-of-life acceptance

Week 1: prep; Week 2: dosing; Week 3–4: integration

Ketamine

0.5–1 mg/kg IV or 50–100 mg IM/sub-lingual

Assessment for cardiac/mental health; intention-setting; brief mindfulness exercise

40–60 minutes; patient monitored in reclining chair or bed

Medical monitoring of BP, HR, O2; therapist present for guidance

Integration session within 1–3 days; journaling, mindfulness, reflection

1–5 sessions over 1–3 weeks depending on response

LSD

100–200 μg oral

1–2 preparatory sessions; psychological assessment; grounding exercises

6–12 hours; eyeshades, music, therapist support; optional guided meditations

Comfortable, private room; at least 2 trained facilitators; emergency protocols in place

Integration session(s) 1–3 days later; discussion of mystical experience, emotional release, acceptance of mortality

Prep: 1–2 weeks; dosing: 1 day; integration: 2–3 days post-session

MDMA

75–125 mg oral

1–2 prep sessions: trauma review, intention setting, coping strategies

6–8 hours; therapist-guided; supportive music; optional gentle touch

Two therapists present; patient encouraged to focus on emotional processing; safe, private setting

Integration session 1–3 days post-dose; reinforce emotional breakthroughs, relational repair

Prep: 1–2 weeks; dosing: 1 day; integration: 1–2 days post-session

Ayahuasca (DMT + MAOI)

2–5 ml/kg decoction, potency varies

Pre-ceremony diet & mental preparation; intention setting; spiritual guidance

4–8 hours; ceremonial space; guided by experienced shaman or facilitator; chanting, singing, ritual tools

Supervised; attention to vomiting/purging; safe environment for introspection

Integration session(s) 1–3 days later; journaling, discussion, spiritual counseling

Prep: 1–3 days; ceremony: overnight; integration: 1–3 days after

Peyote / San Pedro (Mescaline)

200–400 mg mescaline equivalent

Preparatory counseling; spiritual/ancestral intention; fasting or dietary guidance

6–10 hours; ceremonial setting; singing/ritual, guided reflection

Facilitator or shaman present; safe space for emotional release

Integration 1–3 days later; processing visions, ancestral connections, death acceptance

Prep: 1–2 days; dosing: 1 day; integration: 1–3 days after





Additional Protocol Details



  1. Music & Ritual Guidance:
    • Carefully curated playlists help guide emotional peaks and valleys.
    • Rituals may include breathwork, chanting, or gentle touch depending on substance and tradition.

  2. Integration Techniques:
    • Journaling, drawing, or storytelling to consolidate insights.
    • Mindfulness or meditation exercises to reinforce acceptance and presence.
    • Conversations with loved ones to repair relationships or express gratitude.

  3. Safety Measures:
    • Vital signs monitored for ketamine or high-dose psychedelics.
    • Emergency medications or protocols in place for rare adverse reactions.
    • Psychological support always available during challenging experiences.

  4. Customization:
    • Each patient’s dosage, session length, and integration plan are tailored to health status, mental state, and spiritual beliefs.





If you want, I can create a visual “flowchart-style protocol” showing the full week-by-week sequence from preparation to integration—essentially a ready-to-use clinical roadmap for end-of-life psychedelic therapy.


Do you want me to make that?


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