COVID O

ABO Phenotype and Death in Critically Ill Patients With COVID-19

British Journal of Haematology

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• The authors of this retrospective multicenter cohort study reviewed mortality associated with ABO phenotype in 3239 critically ill patients with COVID-19 infection. The 28-day mortality rate was 39.3% and was similar across ABO phenotypes, unchanged by Rh group. In subgroup analysis by ethnicity, critically ill white patients with blood type A were over-represented and type O was under-represented compared with frequencies identified in the general population. The authors note several limitations of this study, including missing ABO blood types for approximately one-third of patients and the limited ability to account for potential confounding factors.
• In patients with COVID-19 infection, type A blood may be associated with a higher likelihood of developing a severe infection requiring ICU admission than type O blood among white patients. Larger cohort studies are necessary to confirm these findings.