Association Between Prediabetes and Risk of All-Cause Mortality and Cardiovascular Disease

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This meta-analysis used data from 129 prospective cohort studies or post hoc analyses of clinical trials (10,069,966 individuals) to examine the relationship between prediabetes and the risk of incident cardiovascular disease and all-cause mortality. There was an association between prediabetes in the general population and increased risk of all-cause mortality, stroke, coronary heart disease, and composite cardiovascular disease. The absolute risk difference in prediabetes versus normoglycemia ranged from 3.68 per 10,000 person-years for stroke to 8.75 per 10,000 person-years for composite cardiovascular disease.

Based on these data, prompt detection of prediabetes and appropriate treatment may help to prevent cardiovascular disease both in the general population and in individuals with existing atherosclerotic cardiovascular disease.