Here’s a concise summary of Mislu et al. (2024): a prospective follow-up study on mortality among low-birth-weight (LBW) neonates receiving parenteral nutrition.
🧷 Study Details
- Design: Prospective cohort of LBW neonates (<2.5 kg) admitted to NICU; followed during hospital stay.
- Setting: Published May 9, 2024, in Research and Reports in Neonatology .
- Sample: Exact cohort size not mentioned in abstracts; full text likely details this.
Key Findings
- High mortality: A significantly elevated death rate was observed among LBW neonates on parenteral feeding .
- Time-to-event analysis: Kaplan–Meier curves in the study highlighted critical periods of mortality ().
- Risk factors:
- Lower birth weight correlated with higher mortality.
- Additional risk factors likely include gestational age, underlying conditions, infections, though specifics require the full article.
Interpretation & Context
- Clinical implication: LBW infants relying on parenteral nutrition remain at very high risk, stressing the need for intensified monitoring, infection prevention, and strategies for transitioning to enteral feeding.
- Literature context: Aligns with global evidence showing the inverse association between birth weight/gestational age and neonatal morbidity/mortality .
What’s Next?
To fully interpret these results and apply them in practice, it would help to review:
- The full text for detailed methodology, sample size, statistical analyses, and adjusted hazard ratios.
- Comparisons with prior studies (since some LBW cohorts have 20–30% mortality) to assess if parenteral feeding posed additional risk here.
Would you like help locating the full PDF, diving deeper into the statistical analysis, or comparing with other research cohorts?
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