15 biomarkers x superager

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A recent study published in Nature has identified 15 blood biomarkers that may predict "SuperAger" status—individuals over 65 whose cognitive abilities rival those of people decades younger. Using machine learning on data from 81 participants, researchers found these biomarkers could predict exceptional cognitive performance with over 75% accuracy .(Super Age)

Key Findings:

• Glucose: Levels below 92 mg/dL supported attention and visuospatial skills, while levels above 100 mg/dL were linked to better verbal memory.(Super Age)

• HDL Cholesterol: Higher levels (>54 mg/dL) consistently contributed to SuperAger classification, supporting language, memory, and executive functions.(Super Age)

• ALT (Alanine Aminotransferase): Levels above 17 U/L were positively associated with SuperAger status, suggesting liver health's role in brain resilience.(Super Age)

• MCHC (Mean Corpuscular Hemoglobin Concentration): Lower values (<34 g/dL) were linked to SuperAger status, though mechanisms remain unclear.(Super Age)

• AGE (Advanced Glycation End-products): Unexpectedly, higher levels (>15 ng/mL) aligned with SuperAger classification, challenging conventional views.

• Oxidized LDL (oxLDL): Lower levels (<51 ng/mL) were associated with better visual and visuospatial performance.(Super Age)

• CD36: Levels above 40 ng/mL correlated with improved visual memory and visuospatial skills.

• Insulin: Levels above 10 µIU/mL were linked to SuperAger status, particularly influencing attention and language, though insulin sensitivity may be key.(Super Age)

• Phosphorus: Levels above 3.5 mg/dL were associated with better performance in memory and attention domains.(Super Age)

• Creatinine: Lower levels (<0.9 mg/dL) were linked to SuperAger classification, suggesting a connection between kidney function and cognitive health.

• Uric Acid: Levels below 5.5 mg/dL were associated with better cognitive performance, particularly in memory and attention.

• Homocysteine: Lower levels (<10 µmol/L) correlated with improved cognitive function, aligning with existing literature on its neurotoxic effects.(Super Age)

• Vitamin D: Levels above 30 ng/mL were associated with better cognitive performance, supporting its role in brain health.

• CRP (C-reactive protein): Lower levels (<1 mg/L) were linked to SuperAger status, indicating reduced systemic inflammation.(Super Age)

• IL-6 (Interleukin-6): Lower levels (<2 pg/mL) were associated with better cognitive function, highlighting the impact of inflammation on brain health.

These findings suggest that a nuanced metabolic and inflammatory profile, detectable through standard blood tests, may be indicative of exceptional cognitive aging. While further research is necessary, this study offers a promising avenue for identifying and understanding factors contributing to cognitive resilience in older adults .(Super Age)