OI

Blue sclera is a hallmark clinical feature of Osteogenesis Imperfecta (OI) — particularly associated with the milder forms, most classically:

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OI Type I (Most Common and Mildest Type)

• Blue sclera is very prominent.
• Normal or near-normal stature.
• Fractures usually occur in childhood and reduce after puberty.
• Hearing loss in adulthood may occur.
• No major bone deformities.

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Other Types:

OI Type	Blue Sclera Presence	Severity
Type I	+ + + (very prominent)	Mild
Type II	+ (may be present)	Lethal in neonates
Type III	+ (may fade with age)	Severe
Type IV	± (variable, often absent)	Moderate

✅ Summary:

Blue sclera is most strongly associated with OI Type I.

Let me know if you’d like a visual comparison of sclera appearance or a summary chart of all OI types.